The score still stands as the biggest blowout in major college football since WWII. The definition of "major college football' is somewhat subjective. Wyoming played in the skyline conference, also known as the Mountain States Conference, which i believe was a member of the "University Division," the precursor to modern Division 1. In any event, since WWII, Houston defeated Tulsa 100-6 in 1968. Prior to WWII, George Tech defeated Cumberland 222-0 in 1916. More recently, in 2003, Rockford Collge defeated Trinity Bible College 105-0, but thats obviously not "major" college football.
So whats the point of these useless facts? For those that play college football on playstation, x-box, etc...you can find the Wyoming-Northern Colorado score in the records section.