Yes, the Pokes will beat SDSU (probably, maybe, might). SDSU has one of the worst rush defences in the country. The problem is that Cole will probably turn to a passing game against SDSU.
On the other hand, Wyo is last in TD margins, last in scoring 9.33/game (there are 119 D-1 teams), 115th in pass offense (the three military acadamies are worse), last in turnovers lost, 116th in passes intercepted, and near last in total offense.
Yes, Joe's team will set records this year.