If I got to coach at Wyo, I would bring almost exactly what I do now.
Offense: My own version/formations of the Pistol. 55% rush, 45% pass. I think with the Backs we have and a mobile Brett we could easily average almost 250 yards rushing (even with our offensive line). And in rushing so well I think our passing attack, with the talent at OB and WR, we would have some HUGE play making capabilities.
Denfense: 4-4 or 5-3. Yes, our coverage is horrid right now, so why add more kids back in coverage and confuse them with even more assignments and have several blown coverage's and give up more big plays every game? So, I would play straight up man coverage with what I have already in the the backfield. I would then use all I could to manhandle the opponents Offense rushing and "in theory" hope to either get to or disrupt their QB enough that he make bad passes. When you have 5, 6 or 7 defenders rushing you, it will take a toll. The line will get tired, The QB will not only be tired from running all night, but should be frustrated and our coverage good enough to protect any passes that could be completed.
My team just played the best offense in Kansas last week. Great rushing team and the best passing team in the state. We typically run a 4-4 and we went 5-3 and blitzed on every other first down and EVERY third down. Their QB who all season has completed 65% passing and averaged 225 yards through the air, went 11-32-99-0-1. We decimated their running game as well. It can work in Laramie.